You can edit mapping of AE shortcut keys in a preference file but this is much easier. As noted last month there's a new release by Jeff Almasol at Adobe Exchange. Part of Additional Scripts for After Effects CS3 is KeyEd Up, which gives you a UI to modify shortcut keys in After Effects.
Jeff also likes his Launch Pad script for "its coolness and ability to associate icons with scripts," and also he's posted screenshots of some of his updated scripts at Flickr. Numerous other script and expression resources were listed in an earlier post Scripts Galore and as Panels in AE8.